LINC00857 contributes to proliferation and lymphomagenesis by regulating miR-370-3p/CBX3 axis in diffuse large B-cell lymphoma

Abstract Diffuse large B-cell lymphoma (DLBCL) remains to be a high aggressive and invasive malignancy with enigmatic etiology. Ectopic expression of long non-coding RNAs is widely involved in the progression human cancers. We discovered that LINC00857 level was remarkably elevated DLBCL tissues compared non-tumor controls. High predicts lower survival rate, more advanced tumor node metastasis larger size. overexpression promoted cell proliferation facilitated cycle as evidenced by Cyclin D1 proliferating nuclear antigen (PCNA) accompanying reduced p21 level. also suppressed apoptosis Bcl-2 protein level, Bax cleaved caspase-3 levels. On contrary, knockdown using short hairpin inhibited yet induced apoptosis. repressed growth vivo, concomitant decreased Ki67 Besides, microRNA miR-370 down-regulated served competitive endogenous RNA (ceRNA) target LINC00857. further validated chromobox homolog 3 (CBX3) downstream gene miR-370-3p. reversely correlated miR-370-3p positively CBX3 In addition, alleviated impact on survival. conclusion, our findings indicated contributes lymphomagenesis through regulating miR-370-3p/CBX3 axis.